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Tubulin polymerization-IN-47

CAS No. 2834087-62-4

Tubulin polymerization-IN-47( —— )

Catalog No. M37020 CAS No. 2834087-62-4

Tubulin polymerization-IN-47 is a tubulin polymerization inhibitor and mitotic inhibitor with antitumor activity and inhibitory effects on neuroblastoma cancer cell proliferation, with IC50s of 7 and 12 nM for Chp-134 and Kelly cell lines, respectively.

Purity : >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
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2MG 82 In Stock
5MG 122 In Stock
10MG 202 In Stock
25MG 394 In Stock
50MG 633 In Stock
100MG 861 In Stock
500MG 1701 In Stock
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Biological Information

  • Product Name
    Tubulin polymerization-IN-47
  • Note
    Research use only, not for human use.
  • Brief Description
    Tubulin polymerization-IN-47 is a tubulin polymerization inhibitor and mitotic inhibitor with antitumor activity and inhibitory effects on neuroblastoma cancer cell proliferation, with IC50s of 7 and 12 nM for Chp-134 and Kelly cell lines, respectively.
  • Description
    Tubulin polymerization-IN-47 (Compound 4h) is a tubulin polymerization inhibitor and mitotic inhibitor. Tubulin polymerization-IN-47 inhibits neuroblastoma cancer cell proliferation, with IC50s of 7 and 12 nM for Chp-134 and Kelly cell line.
  • In Vitro
    ——
  • In Vivo
    ——
  • Synonyms
    ——
  • Pathway
    Others
  • Target
    Other Targets
  • Recptor
    Microtubule Associated
  • Research Area
    ——
  • Indication
    ——

Chemical Information

  • CAS Number
    2834087-62-4
  • Formula Weight
    375.42
  • Molecular Formula
    C22H21N3O3
  • Purity
    >98% (HPLC)
  • Solubility
    In Vitro:?DMSO : 125 mg/mL (332.96 mM; Ultrasonic (<60°C)
  • SMILES
    O(C)C=1C=C(C=2C=3N(C=C(N3)C4=CC=C(C)C=C4)C=CN2)C=C(OC)C1OC
  • Chemical Name
    ——

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1. Joshua Thammathong, et al. Fused Imidazopyrazine-Based Tubulin Polymerization Inhibitors Inhibit Neuroblastoma Cell Function. ACS Med. Chem. Lett. 2023.
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